NATURAL EXTRACTS WITH ANTI-MYCOBACTERIUM ACTIVITY ON

Abstract

Non-tuberculous mycobacteria are environmental species of increasing clinical importance in the last years and have been reported as etiologic agent in various types of infections. Generally, they have great intrinsic resistance to ordinary antimicrobials conventional, which motivates to search new pharmacological alternatives, such as those obtained from natural sources. This study evaluated the activity of classic anti-tuberculosis drugs such as streptomycin (SMR), ethambutol (EMB), isoniazid (INH), rifampin (RIF) and crude extracts of plant from the Atlantic Forest (Brazil) against Mycobacterium fortuitum and Mycobacterium malmoense. It was observed the minimum inhibitory concentration (MIC) for M. fortuitum: EMB = 16μg/mL; SMR = 4μg/mL; INH and RIF 1μg/mL; crude extract Plathymenia foliolosa = 200μg/mL. For M. malmoense, MIC were: SMR = 4μg/mL; INH = 1μg/mL and RIF = 0.25μg/mL. EMB did not inhibit bacterial growth of this species. Active crude extracts against M. malmoense were Siparuna arianeae, Cedrela fissilis and Peschiera affinis that showed MIC = 200μg/mL, while Ficus gomelleria showed 100μg/mL.